Diffuse liver damage refers to the manifestation of extensive damage to liver cells due to certain reasons, which is commonly caused by cirrhosis, fatty liver, polycystic liver, liver cancer and so on. 1. Cirrhosis: Cirrhosis caused by viral hepatitis is more common, which is mainly due to the proliferation of fibrous tissues in the process of self-repair of liver cells after extensive damage to liver cells caused by viruses, affecting the function of normal liver cells, and in serious cases, liver fibrosis or even cirrhosis is formed. 2. Fatty liver: after the surface of liver tissue is covered by a large amount of fat, it will affect the metabolic function of the liver, and the liver cells will be extensively and diffusely damaged due to the continuous stimulation of fatty liver, and in serious cases, it can be developed into liver fibrosis and cirrhosis. 3. Polycystic liver: Polycystic liver is a hereditary disease, due to most of the liver cells are occupied by multiple cysts, which will cause abnormal metabolic function of the liver and liver loss of compensation, and in serious cases, it will cause diffuse damage of the whole liver. 4. Hepatocellular carcinoma: primary hepatocellular carcinoma or metastatic hepatocellular carcinoma cancer foci will invade normal tissues of the liver and affect liver cell function, and the continuous development of the disease will cause extensive diffuse liver damage, and in serious cases, it can cause liver failure. After the occurrence of diffuse liver damage, it is necessary to go to the hospital in time to check the specific cause of the disease and treat it in time, so as to avoid delaying the condition.