The earliest typical symptoms of leukemia are anemia, fever, bleeding, and enlarged liver and spleen lymph nodes. Leukemia is divided into acute leukemia and chronic leukemia. 1. Acute leukemia has both rapid and slow onset, and those with rapid onset often show sudden onset of high fever and severe bleeding, while those with slow onset usually show anemia, pallor, and ecchymosis of skin and mucous membranes. 2. Chronic leukemia has a slow onset, with typical symptoms such as severe anemia, bleeding, and enlarged liver and spleen lymph nodes. (1) Generally, the first symptom is anemia, such as pale skin, and the anemia is gradually aggravated, often manifested as normocytic normochromic anemia, accompanied by fatigue, shortness of breath, tinnitus, loss of vision and other symptoms. Severe anemia can also lead to heart failure. (2) Bleeding may involve all parts of the body, with symptoms such as ecchymosis, bleeding gums, nosebleeds, and excessive menstruation in women. (3) Chronic myeloid leukemia is often characterized by hepatosplenomegaly, with the spleen being the most prominent, often reaching the umbilicus or below the umbilicus. Chronic lymphocytic leukemia often has enlarged lymph nodes, mostly in the neck, supraclavicular region, armpit and groin. Specific diagnosis and treatment should be made under the guidance of a physician.