When taking azithromycin, you should not drink alcohol. Azithromycin is a macrolide broad-spectrum antibiotic, which is mainly metabolized through the human liver and has certain toxicity to the liver, and wine is also mainly decomposed and excreted through the liver. If you drink alcohol while taking azithromycin, this will increase the metabolic burden of the liver and even lead to different degrees of liver function damage. In severe cases, acute liver failure may be triggered. Therefore, when taking azithromycin, do not drink alcohol and take it after meals if necessary to avoid the obvious side effects of gastrointestinal irritation.