Acute hepatic necrosis means that a large number of liver cells are damaged and necrotic within a short period of time, and there is a significant decrease in liver function. It may be caused by acute hepatitis, immune diseases and other reasons. 1. Acute hepatitis: Acute hepatitis generally refers to diseases caused by impaired liver function, usually due to food poisoning, drug damage, hepatitis virus infection, alcoholic liver disease and other multi-causes, of which hepatitis B virus infection leading to acute severe hepatitis is common. Patients may have fever, fatigue, loss of appetite and other symptoms, and gradually develop neuropsychiatric symptoms, including drowsiness, personality changes, irritability, coma and so on. 2. Immune disease: Immune disease is generally a disease in which the autoimmune system is damaged, which leads to problems with the immune system, which may be caused by immune system disorders, genetic factors, etc. Patients may have symptoms such as fatigue, poor appetite, nausea, etc. There are many other causes of acute hepatic necrosis. Patients should go to the hospital as soon as possible to find out the cause of the disease and treat it under the guidance of the doctor.