Mesenchymal large cell lymphoma is a malignant tumor of the blood, one of the non-Hodgkin’s lymphomas of the blood, is relatively common, the so-called malignant tumors are treated in no more than three ways, chemotherapy, radiotherapy, surgery, and for some inert lymphomas can be observed and wait. So mesenchymal large cell lymphoma is an aggressive and progressive lymphoma, so it must be treated, and the choice is not to advocate surgery, so chemotherapy can be chosen. Chemotherapy because there is no very specific targeted therapy. Chemotherapy is preferred to most classical CHOP chemotherapy, and anthracycline chemotherapy drugs. After chemotherapy, if the patient is financially well off and relatively young, and belongs to the high-risk group, he can also choose autologous stem cell transplantation, which is more effective. In rare cases where the effect of chemotherapy is slightly lacking and there is still tumor residue, radiotherapy can also be used as a complementary treatment. However, for older mesenchymal large cell tumors, the dose of chemotherapy should be reduced, otherwise the toxicity associated with some drugs of chemotherapy increases the risk of infection and leads to increased mortality.