Bitten by a spider, you can take topical medication as well as oral medication to reduce swelling and pain. 1. Topical medicine: After being bitten by a spider, local edema and itching will appear, so the local area can be washed with water or soapy water, and then ice pack can be used to ice compress and elevate the affected area, and the local area can be coated with glucocorticosteroid ointment, such as mometasone furoate cream, tretinoin cream, etc, to anti-inflammatory and relieve itching. If it is suspected that the poisonous spider bite, you need to squeeze out the venom first, and then immediately sent to the hospital for treatment. 2. Oral medication: After being bitten by a spider, if the itching is severe, you can take oral antihistamines, such as loratadine, cetirizine and so on. Systemic symptoms such as generalized weakness, headache and nausea may occur after being bitten by venomous spiders. Therefore, it is recommended to go to the emergency room of the hospital immediately after being bitten by spiders, if you are not sure whether it is a venomous spider bite or not.