The golden triad of antibiotics for appendicitis is cephalosporins, quinolones, and anti-anaerobic drugs. Cephalosporins include second-generation cephalosporins, or third-generation cephalosporins; anti-anaerobic drugs include metronidazole or ornidazole or tinidazole. Of course, triple therapy is no longer advocated in the treatment of appendicitis because the current environment is particularly strict in the control of antibiotics, except in the case of abscesses in the abdominal cavity of the appendix and refractory appendicitis, where triple antibiotic therapy may be used. In general, appendicitis requires prompt surgical treatment after diagnosis, which is routinely performed by appendectomy or laparoscopic appendectomy. After conservative treatment of appendicitis, many patients experience recurrence 3 months or even longer after surgery.