Which HPV high-risk type is the most severe

HPV high-risk infections, types 16 and 18, are the most serious, and these two types of HPV infections are capable of causing 70-80% of cervical cancer. Once HPV infection of types 16 and 18 is done, colposcopy is needed regardless of whether there is any abnormality in TCT, which is cervical liquid-based cytology. A biopsy can be taken under colposcopic observation to determine whether there is precancerous lesion of the cervix or cervical cancer based on the pathology results. The vast majority of cervical adenocarcinomas are caused by HPV infection of type 18, so it is important to pay attention to these two types of viral infections whenever they are present.