There are differences between malaria and dengue fever in terms of pathogens, transmission routes and clinical manifestations. 1. Pathogen: the pathogen of malaria is Plasmodium, which is a parasite, while the pathogen of dengue fever infection is dengue virus, which is the most essential difference between the two. 2. Transmission: malaria is transmitted by Anopheles mosquitoes, while dengue fever is transmitted by Aedes mosquitoes. In addition, the epidemic area of malaria is mainly concentrated in the African continent, while dengue fever is mainly prevalent in tropical and subtropical areas. 3. Clinical manifestations: malaria fever is mainly manifested as intermittent fever, while dengue fever is mostly irregular fever, in addition, malaria systemic toxicity symptoms are relatively light, while dengue fever systemic toxicity symptoms are more serious, mostly accompanied by muscle pain. Malaria and dengue fever are both infectious diseases, and once they appear, they should immediately seek medical attention and be treated and isolated under the guidance of a doctor.