We know that people with diabetes have a higher risk of cardiovascular disease compared to people with normal blood glucose. So, do people who are not diagnosed with diabetes and whose randomized blood glucose levels are not at diabetic levels have a reduced risk of cardiovascular disease? A recent study of more than 460,000 people followed for 7 years in the China Chronic Disease Prospective Study showed that even when blood glucose levels were within the normal range, the risk of cardiovascular disease still increased as random blood glucose rose. Here is an explanation of the concept of random blood glucose: Random blood glucose (GLU) is the value of glucose content in millimoles per liter (mmol/L) measured by drawing human venous blood or peripheral blood at any moment, which is the most commonly used test for diabetes and reflects pancreatic β-cell function and generally represents the basal insulin secretion function. Studies have shown that the risk of cardiovascular disease increases with random blood glucose levels from >4.0 mmol/L onwards. At random blood glucose levels >5.9 mmol/L, each 1 mmol/L increase was associated with an 8-11% increased risk of severe ischemic cardiovascular disease and cardiovascular death, and a 5% increased risk of hemorrhagic stroke, as shown in the figure below. (Risk ratios for cardiovascular disease and cardiovascular death at different randomized glucose levels after correction for relevant factors) Note: The above study results were stratified by age, sex, and region, and corrected for education, smoking, alcohol consumption, systolic blood pressure, and physical activity level, All had no history of diabetes, ischemic heart disease, stroke, or transient cerebral ischemia, and 59% were female. The mean randomized blood glucose level at baseline was 5.9 mmol/L, slightly higher in women than in men. At 7 years of follow-up, there were 19,214 deaths, of which 6,645 were due to cardiovascular disease; a total of 3,270 major coronary events, 19,153 ischemic strokes, 22,023 major occlusive vascular disease, and 4,326 hemorrhagic strokes occurred in addition. From the data of the above study, we can easily find that even people without diabetes are at the same risk of cardiovascular disease, and it increases with the increase of random blood glucose level. At present, the incidence of cardiovascular disease in China is increasing year by year and cardiovascular disease is becoming younger. Moreover, we are not yet able to prevent cardiovascular diseases at the root. Therefore, early screening of cardiovascular diseases is especially important.