Bupropion hydrochloride for smoking cessation is clinically effective, and improved medication adherence can lead to better efficacy. Bupropion hydrochloride is a dopamine and norepinephrine uptake inhibitor, belonging to the antidepressant. It is available in immediate-release and extended-release formulations. According to a clinical trial that selected 141 patients who used bupropion hydrochloride for smoking cessation, the rate of smoking cessation reached 38.3% within a period of 4 weeks by analyzing their clinical characteristics and adherence to taking the drug. The higher the nicotine dependence the lower the smoking cessation rate, and vice versa. Secondly, standardizing the medication and taking it on time can also greatly improve the smoking cessation rate. It should be noted that for patients with abnormal liver function or renal insufficiency should reduce the frequency and dose of the drug, and patients with a history of epilepsy are not recommended. The drug needs to be used under the guidance of a physician, the application of drugs need to strictly follow the doctor’s instructions, in the process of taking the drug feel uncomfortable, should immediately stop the drug to the smoking cessation clinic.