In today’s life, the phenomenon of cranial defects is gradually increasing, and cranial defects are usually left behind by trauma or cranial lesions, and debridement and decompression surgery is done. The skull protects the brain, blood vessels and nerves inside the skull, once the defect occurs, it will not only affect the aesthetics, but also cannot protect the tissues inside the skull properly, and it is easy to injure the brain tissues as well as cause the imbalance of the operation inside the skull. Patients with cranial defects usually need to be careful in life, and they dare not do many things and cannot do them, so they will lose their confidence in life over time. What about cranial defects? Cranial defect patients need to perform cranial repair surgery as soon as their condition is stabilized. Although skull repair surgery can be carried out in most general hospitals, but because the surgery involves the human scalp, blood vessels, brain tissue, nerves and other important organs, in addition to the discovery of patients with postoperative complications such as rejection infection, so patients should not take it lightly and must choose advanced and mature skull repair technology. It is reported that polyether ether ketone peek cranial repair, with new high tech molecular peek as implant material, takes embedded repair method, smooth articulation after surgery, strong resistance to striking and low rate of rejection infection. At the same time, we carry out personalized optimization design of materials and innovation and upgrade of surgical techniques, introduce the concept of aesthetic plastic surgery, and develop personalized cranial repair and appearance plastic surgery plan for each patient to ensure precise postoperative repair and natural beauty of symmetry on both sides of the shape. PEEK material is the best choice for skull repair and can be customized in three dimensions according to the extent of the patient’s skull defect. Especially for pediatric patients, it can better accommodate the growth and development of autologous cranial bone.