A missing piece of the skull is scary to hear, and if left untreated, the consequences will be even worse. The reason is that the skull serves as a barrier for the brain tissue, and it is under the protection of the skull that the brain tissue will not be easily attacked by the outside world. Once there is a defect in the skull, the tissues inside the skull will be in danger, which is not good for your safety and health, so you have to go to the hospital to have a skull repair surgery. There is a timing issue with any surgery, and good timing is better for the surgery, and skull repair surgery is no exception. When is the best time to do skull repair? Cranial repair surgery should not be done too early or too late. For patients with open comminuted skull fracture with good wound cleanliness and no intracranial hypertension, one-stage craniovertebral osteogenesis is recommended. For patients with severe closed craniocerebral trauma, cranial defects caused by intracranial hypertension requiring decompression of the desmoid bone flap need to be repaired three months after surgery. The timing of cranial repair is important, and likewise the choice of materials for cranial repair is critical. Many local hospitals now use titanium mesh for cranial repair, which is a more advanced material than previous materials, but has some drawbacks and shortcomings, and is not ideal for postoperative problems. In contrast, the PEEK material that our team is currently using is much more advantageous. It is a very advanced and mature material with excellent properties, effectively avoiding the defects and shortcomings of titanium mesh. Moreover, our team has introduced the concept of cosmetic surgery into the operation, making the postoperative result more natural and beautiful, which is highly praised by the patients.