The cranium is a very important group of bone tissue in the human body, located above the spinal column, consisting of 23 bones of different shapes and sizes. They are very delicate articulation bite together, constituting a complete closed cranial cavity, for the brain and head and face organs to provide important protection and support, for the whole body’s health and the operation of life has a very important significance. However, human beings are in a very complex social environment, there are a variety of external risk factors, danger, and may always be subject to external aggression. The human skull is also in such danger, such as traffic accidents, production safety accidents, falling objects, fights, etc. may cause cranial depression or even cranial defects. What is the treatment for depressed skull? As a rule, an open depressed skull fracture requires surgical debridement and repositioning, with the main goal of minimizing the occurrence of infection. If the degree of depression is greater than the thickness of the adjacent cranial vault, then closed (simple) depressed skull fractures also require surgical repair, which theoretically can aesthetize the appearance, reduce late seizures in post-traumatic epilepsy as well as reduce ongoing neurological deficits. However, despite being widely practiced and theoretically sound, only a small body of literature supports these treatment strategies. 1. Indications for Surgery Patients with open (compound) skull fractures depressed beyond the thickness of the skull itself should undergo surgery to prevent infection. Patients with open depressed skull fractures may be treated nonoperatively if there is no clinical or imaging evidence of dural penetration, significant intracranial hematoma, depression greater than 1 cm, involvement of the frontal sinuses, significant cosmetic deformity, wound infection, intracranial pneumoperitoneum, or significant wound contamination. Nonoperative treatment is a treatment option for closed (simple) depressed skull fractures. Timing Early surgery is recommended to minimize the incidence of infection. 3. Methods Pry up and repositioning and debridement are recommended as surgical treatment options. Surgery in the absence of wound infection and reduction of the original fracture fragments is a surgical treatment option. All treatment strategies for open (compound) depressed fractures should include antibiotic therapy.