The common causes of pain in the area where the plantar big toe meets the ball of the foot include physiologic pain, bunion, trauma, metatarsalgia, and inflammatory joint lesions. 1. Physiological pain: Inadequate shoe size, prolonged walking, and localized friction can cause pain in the area where the plantar big toe meets the ball of the foot. Generally, there is no need for special treatment, so just wear comfortable, appropriate shoes and avoid excessive friction. 2. Bunion: Bunion is a kind of bone deformity, which is more common in women, and pain is the main symptom, often combined with bursitis and walking limitation. x-ray examination can be clear. 3. Trauma: Acute localized injuries to the toes or metatarsophalangeal joints as a result of sports result in pain in the big toe and the ball of the foot, and in severe cases, there are fractures and dislocations. 4. Metatarsalgia: persistent burning pain on the metatarsal side of the forefoot due to strain on the transverse arch of the forefoot or compression of the plantar phalangeal nerve, which can be relieved by rest, and is more common in middle-aged and old weak women. Conservative or surgical treatment should be chosen after clarifying the type. 5. Inflammatory joint disease: metatarsophalangeal arthritis, bunions, gouty arthritis, etc., will appear in the big toe and foot pain symptoms, according to the condition of the targeted treatment. There may be other reasons for pain in the area where the big toe and the ball of the foot are connected. If the symptoms are not relieved for a long time, it is recommended that you go to the hospital in time to improve the examination and clarify the cause of the problem, and then give targeted treatment or therapy.