The best treatment for multiple myeloma should be chosen according to the different conditions, which includes supportive therapy, chemotherapy, stem cell transplantation and so on. 1. Supportive treatment: such as erythropoietin can be used for anemia, and bisphosphonates can be used for hypercalcemia. 2. Chemotherapy: chemotherapy programs include: bortezomib + cyclophosphamide + dexamethasone; thalidomide + dexamethasone; lenalidomide + dexamethasone; dexamethasone + thalidomide + cisplatin + adriamycin + cyclophosphamide + etoposide. 3. Stem cell transplantation: for patients with poor results of the above treatments and meeting the criteria for bone marrow transplantation, stem cell transplantation can be chosen. To improve the survival rate of patients. For asymptomatic patients with multiple myeloma, no treatment can be done for the time being, and observation should be strengthened and regular review should be conducted. Different treatment methods should be adopted for different patients and different stages of development. It should be noted that patients with multiple myeloma can reduce the adverse effects of the disease through “early detection, early diagnosis and early treatment”, and many of them may survive for a long time, so it is recommended that patients establish confidence in treatment. All the above medications should be used under the guidance of a doctor, avoid self-medication.