Biliary tract motility dysfunction manifests as abdominal pain, which is paroxysmal colic in the upper abdomen or right upper abdomen. Some patients may have nausea and vomiting, which can be induced by eating fatty foods and often lasts for 2 to 3 h. The symptoms are relieved with antispasmodics. Differential diagnosis of biliary tract dysfunction: 1, lower bile duct stones: need to be distinguished from papillary sphincter spasm and organic lesions involving the common bile duct, which can be distinguished by duodenoscopic retrograde cholangiopancreatography (ERCP) and percutaneous transhepatic cholangiography (PTC). 2, gallbladder (duct) stones: can lead to gallbladder dilatation, need to be distinguished from hypertonic gallbladder and hypokinetic gallbladder, diagnostic imaging (ultrasound, CT and MRI) can be found gallbladder (duct) stones, so as to confirm the diagnosis. 3, lack of special peri-potbelly inflammation and infection: its manifestations can be similar to the increased tension of the sphincter of Oddi, but most of them can be confirmed by endoscopy. 4, peri-pot belly and pancreatic head tumors: can be distinguished from increased sphincter of Oddi tone by ultrasound, endoscopy, PTC and other imaging examinations and surgical exploration. 5, chronic pancreatitis: its clinical manifestations can be similar to biliary motility dysfunction, but the former can have a large number of fat droplets and undigested muscle fibers in the stool, and several imaging examinations can reveal changes in the shape of the pancreatic duct and pancreas. 6, atypical angina pectoris and myocardial infarction: the clinical manifestations can be similar to biliary tract motility dysfunction, but electrocardiogram and/or myocardial enzyme spectrum examination can reveal corresponding changes of heart disease.