Medial knee pain may be a manifestation of soft tissue injury caused by trauma, excessive activity, or a symptom caused by osteoarthritis, as follows: 1. When the patient’s knee joint has been impacted by external forces, aseptic inflammation of the medial local soft tissues may occur, causing inflammatory factors to ooze out and pain to appear. 2. If the patient is prone to tear or strain of the medial collateral ligament or medial meniscus after strenuous and excessive activities, the patient will experience pain in the medial side of the knee joint with the pulling or squeezing when the knee joint is moved again. 3. If the patient has degenerative changes in the knee joint, the anterior medial cartilage is often worn out, and there is a lack of lubrication and cushioning tissues during activities, which makes it easy for pain to occur.