As a stress hormone, adrenaline secretion increases when the body is stressed and emotionally excited and nervous. If a patient presents with persistently high adrenaline levels and shows corresponding clinical symptoms, such as increased concentrations of adrenaline in blood and metabolites of adrenaline in urine detected after blood sampling, pheochromocytoma or paraganglioma needs to be investigated. If the diagnosis of pheochromocytoma or paraganglioma is clear, surgery is preferred. Preoperative medication for about 4 weeks is required to avoid life-threatening intraoperative and postoperative fluctuations in the patient’s blood pressure; long-term postoperative follow-up is also required. In addition, patients can also choose radioactive iodine therapy, local chemotherapy, and local embolization.