Dry syndrome and rheumatoid arthritis belong to the same connective tissue disease among rheumatic diseases, both diseases are highly related to rheumatoid factor, and in the opinion of rheumatologists dry syndrome and rheumatoid arthritis have the same seriousness. Because of rheumatoid arthritis, most of the patients have joint symptoms as the main clinical manifestation, and in the late stage of the disease, if the disease is serious, it can lead to joint deformation, which can seriously affect the quality of life, and serious patients are not even able to take care of themselves. In addition, rheumatoid arthritis can affect the interstitial lung, resulting in interstitial lung lesions, severe interstitial lung fibrosis, which can cause a decrease in blood oxygen concentration, pulmonary hypertension, pulmonary heart disease and a series of other diseases, and in serious cases can endanger life. Dry syndrome also has symptoms of joint swelling and pain, but compared with the joint symptoms of rheumatoid patients, the joint symptoms of dry syndrome patients are relatively milder, and the rate of joint deformation and the degree of joint deformation are also milder than those of rheumatoid arthritis patients. However, patients with dry syndrome will have obvious dry mouth and eyes, which means that the exocrine glands have abnormalities, resulting in dry mouth, dry eyes and dry nose, and some people may also have damage to the gastric mucous membrane glands, resulting in difficulty in eating, difficulty in swallowing, indigestion and other manifestations. Patients with dry syndrome may also suffer from interstitial lung lesions and renal tubular acidosis and other organ damage, which may also be life-threatening in serious cases. In addition, the chance of lymphoma in patients with dry syndrome is more than 40 times higher than the incidence of normal people. Therefore, during the treatment of patients with dry syndrome, doctors should closely monitor the changes of the disease to prevent or detect these complications that may easily cause life safety.