High C-reactive protein but normal white blood cells suggests that the patient has an inflammatory reaction, but not necessarily a bacterial infection. It is seen in the early stages of bacterial infections, non-bacterial infections, rheumatic immune diseases, and tumors. 1. In the early stage of bacterial infection, C-reactive protein will be increased, but the total number of leukocytes may not be elevated for the time being, presenting a false negative. Inflammation caused by mycoplasma infection will cause high C-reactive protein, but mycoplasma is an atypical pathogen and does not belong to bacteria, so there will be no elevation of leukocytes. 2. Rheumatic disease is an autoimmune disease, because it is not a bacterial infection, the total number of white blood cells will not be elevated, but because it will cause autoimmune inflammation, so there is a high C-reactive protein. 3. Tumors can secrete growth factors and many kinds of inflammatory mediators, leading to inflammatory reaction, so it shows high C-reactive protein, but there is no leukocyte elevation. High C-reactive protein is recommended to go to the hospital for further detailed investigation.