Soreness in the leg socket and calf behind the knee can be caused by osteoarthritis, popliteal cysts, or inflammation of the tendon fascia, which clinically requires treatment with NSAIDs or surgery, depending on the condition. Soreness in the leg fossa and calf behind the knee is most likely due to osteoarthritis. Osteoarthritis can cause fluid leakage from the joint cavity as well as localized edema, resulting in soreness and pain in the popliteal fossa and calf, and the patient can be treated with non-steroidal anti-inflammatory drugs for anti-inflammation and pain relief, such as Celecoxib, and subcutaneous glucocorticosteroids can be used to alleviate inflammation in cases where the localized symptoms of inflammation are severe. If the patient’s popliteal cyst symptoms are serious, compression of the common peroneal nerve or other neurovascular, this situation requires surgical treatment to relieve the compression symptoms. If the symptoms are serious or continue to be unrelieved, it is recommended to consult a doctor in time to clarify the diagnosis and carry out targeted treatment.