Cardiac puncture is a therapeutic tool with strict indications and contraindications; cardiac puncture may not be recommended due to no therapeutic indication or contraindications. Most of the clinical terms for cardiac puncture refer to pericardiocentesis. Pericardiocentesis is used to relieve large amounts of pericardial effusion leading to cardiac tamponade, diagnostic puncture of pericardial effusion for etiologic diagnosis, and therapeutic intrapericardial drug administration. Pericardiocentesis is contraindicated in cases of abnormal coagulation, presence of bleeding disorders such as hemophilia, undergoing anticoagulation therapy, presence of bacteremia or sepsis, and unstable mental status that prevents cooperation in completing the operation. In the absence of the above indications or contraindications, cardiac puncture is not recommended.