Lung cancer starts to have pain means lung cancer metastasis to pleura, ribs or bone metastasis throughout the body, all of which are locally advanced or advanced lung cancer. The general 5-year survival rate of advanced lung cancer is about 10%-30%, and the natural survival time is about 0.5-1 year, depending on the advanced metastatic site of lung cancer and the nature of pathology. Currently, the use of targeted drugs for lung cancer with genetic mutations can extend the overall survival time of lung cancer patients, and the use of immune checkpoint inhibitors can also significantly extend the survival time of advanced lung cancer, which is proven by current evidence-based medical evidence. Therefore, it is still possible to actively treat lung cancer starting pain, and the treatment should be based on the pathological type and metastatic site of lung cancer using the appropriate treatment strategy.