Chronic inflammation of the mucosa with intestinal epithelial hyperplasia is serious in terms of pathologic findings alone. Symptomatic considerations may not always be the case, as some patients may be asymptomatic. 1. Pathology: intestinal epithelial hyperplasia is a precancerous lesion, and there is no clear drug that can reverse this pathologic change. Treatment is mainly symptom control and regular review, and early minimally invasive resection should be considered in case of high-grade sarcomatous changes and polyps. 2. Symptoms: chronic inflammation of the mucosa with intestinal epithelial hyperplasia suggests chronic atrophic gastritis. Chronic atrophic gastritis may have symptoms such as acid reflux, heartburn, gastric distension, gastric pain, etc. Some patients do not have related clinical symptoms, only manifested as epigastric discomfort after eating. It is recommended that patients with chronic inflammation of the mucosa accompanied by intestinal epithelial hyperplasia go to the hospital in a timely manner, so that the doctor can determine the condition according to the patient’s specific circumstances.