In general, methotrexate can treat psoriasis. Methotrexate has anti-tumor and immunosuppressive effects, so it is commonly used in patients with tumors (leukemia, lymphoma, etc.) and psoriasis, and can be used alone or in combination with other drugs. In psoriasis, the proliferation of skin epithelial cells is much stronger than that of normal skin, and the use of methotrexate can effectively control the development of the disease. It is often used in severe, stubborn, disabling psoriasis that is insensitive to conventional therapy. Adverse reactions may occur with the use of this drug, including stomatitis, mouth and lip ulcers, pharyngitis, nausea, jaundice, rash, and dizziness. If these symptoms occur, patients are advised to stop the drug and seek medical attention. The drug is contraindicated in pregnant as well as lactating women, patients with severe hepatic and renal insufficiency, and patients with immunological deficiencies. In addition, patients are advised to use methotrexate tablets under the supervision of a doctor and not to use it privately.