Complete prolapse of the rectum is a common and intractable disease in anorectal medicine, with an incidence of 0.53%-1.9% and an average duration of 20 years. Long-term complete prolapse of the rectum will lead to nerve damage in the pubic area and the risk of anal incontinence, ulceration, bleeding, stricture and necrosis, and modern medical treatment is mainly based on transabdominal or perineal surgery. In the 1980s, our hospital invented the anti-hemorrhoid injection, which made a breakthrough in the treatment of internal hemorrhoids and was called “the gospel of hemorrhoid patients”. We have achieved good results. The so-called double-layer four-step injection method refers to the injection of the outer layer of the rectum (perirectal space) and the inner layer of the rectum (submucosa of the rectum) in four steps. The drug (e.g., elimination of hemorrhoid injection) is injected in four steps into: (1) both sides of the pelvic rectal space, so that the rectum and the lateral rectal ligament are fixed; (2) the posterior rectal space, so that the rectum and the presacral fascia are fixed; (3) the submucosa of the rectum, so that the loose rectal mucosa is fixed with the muscle layer, thus achieving the purpose of treatment. So that the rectal mucosa and muscle layer, rectal muscle layer and surrounding tissue adhesion fixed, so as to achieve a better clinical efficacy, is described as follows. 1.Diagnostic criteria: According to the diagnostic criteria of the Clinical Research Guidelines for the Treatment of Rectal Prolapse by New Chinese Medicines of the People’s Republic of China, those who meet the diagnostic criteria of type II rectal prolapse of the whole layer and whose gradation is II or III degree. 2.Treatment method: patients were fed with fluid juice 1 day before surgery, fasted on the day of injection, clean enema, and perineal skin preparation. After successful sacral anesthesia, the patient was placed in a bladder truncated position, and the anorectum was disinfected with iodophor. The injection was completed in four steps as follows. Step 1: Injection in the left pelvic-rectal space. In the bladder truncated position at 3 points 1.5 ml from the anal margin, first penetrate the cortex with a No. 9 lumbar puncture needle, parallel to the anal canal through the external anal sphincter to the levator muscle, and when there is a feeling of falling through the levator muscle, indicate that the pelvic rectal space is entered through the levator muscle. At this time, use the index finger of the left hand to reach into the rectal jugular to guide, touch the tip of the needle, confirm that the lumbar puncture needle is located in the lateral rectal wall, not penetrating the rectal muscle layer, and then the lumbar puncture needle needle oblique to the lateral and all pierced. If the needle is found to be far from the rectal mucosa, it should be re-punctured, and when the puncture site is appropriate, the fingers feel only the muscle layer of the intestinal wall from the needle, and the touch is obvious. After accurate positioning back to draw no blood and then inject the drug. When injecting the drug should be injected while retreating the needle, so that the drug is evenly distributed in a column, and inject 20ml of the original solution of eliminating hemorrhoids. Step 2: posterior rectal gap injection. After replacing the lumbar puncture needle, puncture at the midpoint of the skin between the anus and the tailbone at 6 o’clock in the truncated position. The lumbar puncture needle is first parallel to the anal canal, cross the anal caudal ligament and then slant to the posterior side, in order to make the puncture site correct, still use the other hand index finger into the rectal pot belly for guidance, into the needle about 9 cm. confirm that the needle does not penetrate the rectal wall, not penetrate into the pre-sacral fascia, activity in the posterior rectal space, and then back the needle while injecting 10-15 ml of anti-hemorrhoid original solution. Step 3: right pelvic rectal space injection. Puncture at 9 o’clock in the truncated position according to the previous method and inject 20ml of the original solution of elimination of hemorrhoids. Step 4: Multi-point injection under the rectal mucosa. Place the horn anoscope (2.2 cm in frontal caliber, 5 cm in posterior caliber, 8 cm in length) as far as possible into the rectal terminus, fill a 5 ml syringe with drug solution and attach a No. 5 needle (dentistry anesthesia needle), inject 1-2 ml of drug under the anoscope at 1.3.5.7.9.11 points in the truncated position, then retreat 1 -Then, we injected 2.4.6.8.10.12 points in the same way until above the dentate line. Make the drug injected evenly into the submucosa, and inject 60ml of 1:1 Hemorrhoid Eliminator dilution (1 part of Hemorrhoid Eliminator plus 1 part of 0.50% xylocaine). Caution: strictly perform aseptic operation, and change gloves after each injection step. Master the anatomy of the anal canal rectum and its surrounding tissues. Never inject fluid into the muscular layer of the intestinal wall, the presacral fascia and the abdominal cavity. Do not puncture the intestinal wall. Post-injection treatment: fast or give a dregs-free diet on the day after surgery, take oral antibiotics within one week of injection, and control bowel movements for 3-5 days. If the first bowel movement is difficult, use warm saline 1000 ml enema. Patients pay attention to bed rest, avoid squatting and excessive increase in abdominal pressure. 3, experience Injection therapy for rectal prolapse, has a history of decades, has used a variety of injectable drugs such as 95% alcohol, 50% glucose injection, 5% sodium cod liver oil, 5% petrocarbonate oil, 30% saline, 7% alum injection. The cure rate and complications are different for each dosage form. At present, this method has been less used in foreign countries, in foreign monographs are rarely introduced, or even do not mention this therapy. The reasons for this are: some agents have good results but more complications, some have no complications but low cure rates, and some are very effective and have no complications but are difficult to inject. Overseas injection therapy is mostly used for the treatment of rectal prolapse in children and rarely in adults. In infancy, rectal prolapse is a self-limiting disease. The mechanism of injection is that the inflammatory response causes fibrosis of the outer rectal wall and perirectal tissues, resulting in fixation of the rectal wall to the surrounding tissues, thus preventing prolapse from occurring. We believe that the double-layer, four-step injection of eliminating hemorrhoids for rectal prolapse has the advantages of less pain, lower cost, shorter course, no major complications, and repeatable application, and can be the treatment of choice for rectal prolapse.