Usually, the normal anti-phospholipase A2 receptor antibody is below 20RU/ml. When the anti-phospholipase A2 receptor antibody is higher than 20RU/ml, it suggests that it is likely to be idiopathic membranous nephropathy, and clinically, it can present with nephrotic syndrome, which can lead to renal insufficiency in severe cases.
Phospholipase A2 receptor on glomerular podocytes is the main antigen of idiopathic membranous nephropathy. Circulating anti-phospholipase A2 receptor antibody binds to the phospholipase A2 receptor antigen on glomeruli to become an in situ immune complex, which activates the complement leading to podocyte injury and proteinuria.
The normal value of antiphospholipase A2 antibody is below 20, and this indicator is important for diagnosing membranous nephropathy. Antiphospholipase A2 helps in the diagnosis of idiopathic membranous nephropathy. Antiphospholipase A2 antibody also helps to observe the treatment results of membranous nephropathy as well as the recurrence, etc.
Patients with elevated antiphospholipase A2 antibody should go to the hospital in time, complete the renal biopsy under the guidance of specialized physicians and get timely treatment.