Elevated bilirubin will not directly lead to blockage of bile drainage ducts, but diseases that cause elevated bilirubin may lead to blockage of bile drainage ducts, such as bile duct stones, cholecystitis, and pancreatic head cancer. There are many reasons for bile drainage duct blockage, common ones include bile duct stones, inflammation or narrowing of the bile duct, tumor compression, etc., and these diseases can also cause elevated bilirubin. Bile duct blockage can be followed by symptoms such as yellowing of the skin sclera, itching of the skin, fever, etc. Hepatobiliary ultrasound, CT and ERCP are needed to clarify the specific cause. For patients with bile duct blockage, it is recommended to go to the hospital in time for the doctor to analyze the cause and determine the treatment measures.