Painful pressure on the round bone under the big toe may be due to strain, trauma, big toe deformity, aseptic inflammation and vascular neuropathy. 1. Strain injury: mostly refers to injuries caused by wearing high heels, standing for a long time or climbing mountains, etc., and pain is triggered by pulling the damaged area when pressed. 2. Trauma: Including fractures, ligament and tendon injuries caused by violence and sports, etc., manifested by pain on pressure, redness, swelling and high skin temperature. 3. Big toe deformity: It can be seen in bunion, bunionette, etc. Typical symptoms are painful pressure underneath the big toe and change in the shape of the toe. 4. Aseptic inflammation: mainly refers to bunion synovitis, osteoarthritis, rheumatoid arthritis, gouty arthritis, etc., which may present with painful pressure on the big toe, swollen and protruding joints, and decreased mobility. 5. Vascular lesions: common in vasculitis, diabetic foot, etc., mainly manifested as pain on pressure of the big toe, low skin temperature, claudication, etc.. The cause of the pain of pressing the round bone under the big toe is not clear, it is recommended to go to a regular medical institution, improve the relevant examination, and find out the cause with the help of the doctor.