Prolactin is a syndrome characterized by elevated prolactin (PRL) (≥25ng/ml), amenorrhea, overflow of milk, anovulation and infertility caused by internal and external environmental factors. Etiology The secretion of prolactin is affected by various factors, such as sexual intercourse, mental stress, and strenuous physical activity, which can lead to increased prolactin levels. In addition, progesterone, dexamethasone, adrenal cortisol and other medications, as well as acute stressful situations such as trauma, can all cause increased secretion of prolactin. Some other causes can also lead to increased prolactin, such as primary hypothyroidism, idiopathic amenorrhea, primary hyperthyroidism, renal insufficiency, bronchogenic carcinoma and other diseases. For patients with amenorrhea, ovarian function tests, pituitary function tests, thyroid function tests, adrenal function tests, growth hormone tests, prolactin excitation and inhibition tests, etc. are usually performed, and for some patients, x-ray examinations and visual field examinations are required if pituitary tumors are suspected. Treatment options Once the relevant endocrine tests confirm elevated prolactin, a clear diagnosis is made as soon as possible and appropriate treatment measures are taken. These tests, which must be performed in a hospital, can be performed with the reassurance that the tests themselves are not invasive or painful and should not be a cause for concern. For elevated prolactin caused by medication, it is expected to decrease on its own after stopping the medication. If MRI can accurately exclude pituitary lesions, treatment with bromocriptine may be considered at a dose of 5-10 mg for 1-3 months. Serum prolactin levels need to be reviewed regularly to adjust the medication regimen and implement individualized treatment.