Hyperprolactinemia (HPPL) is a syndrome characterized by elevated prolactin (PRL) (≥25ng/ml), amenorrhea, overflowing breast, anovulation and infertility, caused by internal and external environmental factors. The normal pulsatile release of PRL and its circadian rhythm play an important role in the regulation of mammary gland development, lactation and ovarian function. HPRL can be caused by both physiological and pathological factors. Clinical manifestations 1, menstrual disorders primary amenorrhea 4%, secondary amenorrhea 89%, menstrual scarcity and hypomenorrhea 7%. Luteinizing insufficiency 23%-77%. 2, breast overflow typical HPRL performance for amenorrhea – breast overflow syndrome, in the non-tumor type is 20.84%, tumor type in 70.58%, simple breast overflow 63 ~ 83.55%. The overflow is dominant or occurs when the breast is squeezed, is watery, is plasma, or is milk. The breasts are mostly normal, or with lobular hyperplasia or macromastia. 3. Infertility is caused by anovulation, luteal insufficiency or luteinized unruptured follicle syndrome (LUFS).