Elevated blood PRL, also known as hyper-PRLemia, usually manifests as amenorrhea (or menstrual disorders), breast discharge and elevated blood PRL. There are many causes of its elevation, most of which are due to pituitary tumors. Drugs or other organ diseases can also cause elevated blood prolactin. Common drugs include reserpine, morpholine, ranitidine, cimetidine, oral contraceptives and antidepressants. There are also unexplained (idiopathic) hyperprolactinemia. When elevated PRL is found, it is important to seek medical attention to determine the cause.