Keratosis of the palms and soles of the feet with hyperhidrosis is one of the symptoms of amino acid metabolic disease. With some exceptions, amino acid metabolic disorders are autosomal recessive genetic causes more common in the offspring of consanguineous marriages. So, what can we do to prevent it effectively? The following are preventive measures for keratinization of palms and soles with hyperhidrosis: There are more than 100 hereditary diseases caused by disorders of amino acid metabolism. New discoveries will continue to be added as biochemical testing techniques advance. The main clinical features are normal appearance and activity at birth, with gradual intellectual decompensation after the age of half or one year. Many cases can improve neurological symptoms after appropriate amino acid supplementation and comprehensive treatment with dietary control vitamins. The amino acid metabolism abnormalities that can be controlled by trial dietary therapy, low protein diet, supplementation with semi-synthetic amino acid milk mix without metabolic accumulator amino acids, maple syrup urine disease, urea metabolism disorders of hyperammonemia; restriction of amino acid intake, such as hyperlysinemia. The prognosis of different types of amino acid metabolic diseases varies, and most have a poor prognosis. Epileptic seizures and ataxia are both common biochemical abnormalities that result. Most children present with reduced learning ability and varying degrees of mental decline. Genetic disorders are difficult to treat and have unsatisfactory outcomes, making prevention even more important. Preventive measures include avoidance of consanguineous marriage, introduction of genetic counseling, carrier genetic testing and prenatal diagnosis and selective abortion to prevent the birth of affected children.