Palmoplantar hyperhidrosis is mainly characterized by sweaty palms and soles of the feet. In mild cases, the palms are only moist, while in severe cases, the palms can produce beads of sweat visible to the naked eye. In severe cases, the palms of the hands may produce beads of sweat that are visible to the naked eye. Because the skin of the hand is often moist and soaked, the palm of the hand molts significantly and is often accompanied by dermatitis. In winter, cold and wet extremities can lead to frostbite and skin ulceration. Patients often have sweaty palms since childhood or adolescence, which affects daily life and work. The sweaty hands tend to affect the dexterity of the hands and interfere with manual operations. Patients avoid shaking hands with others, which affects interpersonal communication and creates avoidance and anxiety. The survey showed that 50% of the patients felt a lack of self-confidence and 38% of the patients had a sense of frustration. And the patients who have a sense of depression also reach about 20%. Palmoplantar hyperhidrosis should be differentially diagnosed with the following symptoms: 1, emotional hyperhidrosis Emotional hyperhidrosis is a special type of cortical or emotional sweating that occurs after simultaneous sexual stimulation due to increased secretion of acetylcholine as a result of emotional stimulation. 2, more sweating and odor stronger odd sweat (bromhidrosis) sweat gland secretion with a special odor or salty sweat is released after decomposition of the odor is called odd sweat. Can be divided into two kinds of systemic and localized. In Chinese medicine, the body qi, fox qi and fox odor belong to the scope of this disease. There are two kinds of generalized and restricted sweating. Systemic hyperhidrosis is often moist skin surface, and there are bouts of sweating. Localized hyperhidrosis is common in the palms of the hands, feet and plantars, axillae, followed by the tip of the nose, forehead, pubic area, etc. It mostly develops in adolescents, and patients often have peripheral blood circulation dysfunction, such as wet and cold, bruised or pale skin on the hands and feet, and easy frostbite. Sweaty feet due to poor evaporation of sweat, resulting in impregnation of the epidermis on the soles of the feet and white, often accompanied by foot odor. When the armpit and the pubic area are sweaty, because the skin is thin and tender, often moist friction, easy to occur rubbing erythema, accompanied by folliculitis, boils, etc.