Palmoplantar hyperhidrosis is mainly characterized by sweaty palms and soles of the feet. In mild cases, the palms are only moist, while in severe cases, the palms can produce beads of sweat visible to the naked eye. In severe cases, the palms of the hands may produce beads of sweat that are visible to the naked eye. Because the skin of the hand is often moist and soaked, the palm of the hand molts significantly and is often accompanied by dermatitis. In winter, cold and wet extremities can lead to frostbite and skin ulceration. Patients often have sweaty palms since childhood or adolescence, which affects daily life and work. The sweaty hands tend to affect the dexterity of the hands and interfere with manual operations. Patients avoid shaking hands with others, which affects interpersonal communication and creates avoidance and anxiety. The survey showed that 50% of the patients felt a lack of self-confidence and 38% of the patients had a sense of frustration. The number of patients with a sense of depression also reaches about 20%. The following diseases are the causes of palmoplantar hyperhidrosis: 1, hypertension Hypertension (hypertensive disease) is a chronic disease manifested by a continuous increase in arterial blood pressure, often causing lesions in the heart, brain, kidneys and other important organs and the corresponding consequences. Carcinoid tumor, also known as carcinoid tumor, is a group of chromophobic neoplasms occurring in the gastrointestinal tract and other organs, whose clinical, histochemical and biochemical characteristics may vary depending on the site of occurrence. This tumor can secrete 5-hydroxytryptamine (serotonin), kinins, histamine and other biologically active factors, causing vasomotor disorders, gastrointestinal symptoms, cardiac and pulmonary lesions, etc., called carcinoid syndrome. 3.Concussion A concussion is a transient brain dysfunction that occurs immediately after a blow to the head from an external force. There is no significant change in pathological changes, and the mechanism of occurrence is still much debated. Clinical manifestations are transient coma, near-event amnesia and symptoms such as headache, nausea and vomiting, with no positive signs found on neurological examination. It is the mildest form of brain injury and is mostly curable with treatment. It can occur alone or in combination with other craniocerebral injuries such as intracranial hematoma, and attention should be paid to make a timely differential diagnosis. 4, sweat duct tumor (syringoma) is an adenoma of the small sweat ducts in the epidermis. Histochemical studies have shown that syringoma contains phosphatases and hydrolases typical of the origin of small sweat glands. It is a benign tumor of the sweat ducts that differentiates into the terminal sweat ducts. Some patients have a family history of the disease, and the lesions are found on the eyelids and cheeks. It can be left untreated. Malaria is an insect-borne disease caused by Plasmodium infection through the bite of Anopheles mosquitoes or by importing the blood of a person with Plasmodium. There are four kinds of Plasmodium parasites in human body, namely Plasmodium intergenerum, Plasmodium trisporum, Plasmodium falciparum and Plasmodium ovale. In China, the main parasites are Plasmodium vivax and Plasmodium falciparum; the other two species are rare, and some cases imported from abroad are occasionally seen in recent years. Different Plasmodium parasites cause Plasmodium vivax, Plasmodium trisomy 21, Plasmodium falciparum and Plasmodium ovale. The disease is mainly manifested as periodic regular attacks, generalized chills, fever, and excessive sweating, which can cause anemia and splenomegaly after many long-term attacks. 6.Hyperhidrosis is a disease caused by excessive secretion of sweat glands due to excessive excitation of sympathetic nerves. The sympathetic nerve governs sweating throughout the body. Under normal circumstances, the sympathetic nerve regulates the body temperature by controlling sweating and heat dissipation. In hyperhidrosis, however, sweating and facial flushing are completely out of control. The excessive sweating and facial flushing leave the patient in a daily state of helplessness, agitation or panic.