Aspirin is a drug commonly used in clinical practice. Today, let’s explore the correct usage of aspirin. First, should I take it before or after meals? This is mainly because of the damage of aspirin to the stomach. However, most of the tablets used for cardiovascular diseases are enteric tablets, which have an acid-resistant but not alkaline-resistant envelope outside, and are generally released only in the alkaline environment of the intestine, which can reduce the direct stimulation of the stomach, but only a small amount of decomposition is released in the stomach (according to the pharmacopoeia, the amount released in the stomach is less than 10%, which is qualified). Therefore, according to the pharmacopoeia and the requirements of the drug instructions, it is best to take aspirin enteric tablets before meals. For patients with gastric ulcers, if you must take aspirin, add a gastric mucosal protector (such as famotidine) or proton pump inhibitor (such as omeprazole), and pay attention to the presence of abdominal distension, abdominal pain, nausea and other gastrointestinal symptoms, as well as black stools or even blood in the stool and other symptoms of gastrointestinal bleeding. Second, is it better to take it in the morning or in the evening? At present, according to the “Chinese Expert Consensus on Clinical Application of Aspirin” and other expert consensus on hypertension and coronary heart disease, there are no clear regulations on this issue. However, the anti-platelet aggregation effect of long-term aspirin use is continuous, and there is little difference with taking it in the morning and evening, the key is to take it regularly! All patients who meet the indications for taking aspirin, as long as there are no obvious contraindications and the benefits of taking it outweigh the risks, need to take it regularly for a long time. Scientific understanding of aspirin, follow medical advice to take aspirin correctly, and not blindly stop or reduce the drug, in order to effectively reduce the occurrence of cardiovascular and cerebrovascular diseases.