Excessive intake of trans fatty acids raises the likelihood of developing hypertension, coronary heart disease, atherosclerosis and other diseases of abnormal lipid metabolism, and is also closely related to diabetes, childhood obesity and so on. Trans fatty acids can affect the metabolic process of blood lipids, so that cholesterol, low-density lipoprotein and so on, and make high-density lipoprotein lower, increase the probability of suffering from coronary heart disease, atherosclerosis and other diseases. At the same time, trans fatty acids can also increase vascular lesions through mechanisms such as mediating inflammation and promoting oxidative stress, leading to hypertension and atherosclerosis. Trans fatty acids can also make the probability of developing diabetes much higher by decreasing cellular sensitivity to insulin. There are also studies showing that childhood obesity may also be associated with excessive intake of trans fatty acids leading to changes in dietary structure. Warm tips, in our daily life we should pay attention to reduce the intake of trans fatty acids, improve the quality of life, maintain good health.