If it is non-pregnant progesterone can not make up the consideration is the luteal insufficiency is more serious, if it is pregnant progesterone can not make up the consideration is the embryo is not well developed. 1. Non-pregnancy: progesterone is a natural progesterone secreted by the corpus luteum of the ovary, low progesterone in non-pregnancy will affect normal menstruation, if the progesterone does not come up to the consideration of luteal insufficiency is more serious, even with the use of medication can not reach the normal standard. 2. Pregnancy: If you are pregnant, progesterone is not considered to be related to the poor development of the embryo, under normal circumstances, the value of progesterone will rise after pregnancy, but if the embryo due to chromosomal reasons such as the development of abnormal, it will affect the rise in hormone levels, and at this time, even if the supplemental progesterone may not be able to make up for it. Progesterone is not enough to make up for the problem and should be treated according to the cause of the disease.