Creatine kinase is mainly found in cardiac muscle and skeletal muscle, and the cause of its elevation varies, as does the method of treatment. If the elevation is due to myocardial infarction, anti-platelet aggregation drugs such as aspirin and clopidogrel, lipid-regulating drugs such as statin lipid-lowering drugs, coronary expansion drugs such as isosorbide mononitrate, and even thrombolytic therapy are required. Elevations due to viral myocarditis can be treated with myocardial nutrients, such as coenzyme Q10 and adenosine triphosphate, and elevations due to dermatomyositis can be treated with methylprednisolone, methotrexate, and azathioprine. Elevations due to myotonic dystrophy can be treated with adenosine triphosphate and vitamin E. Elevated creatine kinase due to viral hepatitis can be treated with antiviral drugs such as acyclovir. Elevated serum creatine kinase due to exercise or oral clobetasol requires discontinuation of medication or rest and does not require treatment for the time being, and most of them can return to normal after 1-2 weeks. Elevated creatine kinase should be treated according to different causes and requires different medications. Most elevations caused by physiological factors or medications do not require treatment.