The major difference between creatine kinase and creatine kinase isoenzyme is that creatine kinase is a general term that includes creatine kinase isoenzyme, which is an inclusive relationship. In clinical practice, creatine kinase isoenzyme is more specific than creatine kinase for the diagnosis of myocarditis or myocardial infarction, because there are many factors that can lead to creatine kinase elevation, such as myolysis, muscle injury, excessive exercise, fever, tumor, and severe infection, all of which may lead to creatine kinase elevation. If a patient has an elevated creatine kinase isoenzyme, it often represents some degree of myocardial damage. In addition to this, creatine kinase isoenzymes are also useful in predicting roughly what the current area of myocardial necrosis is, which is the difference between the two.