When there is an increase in creatine kinase and lactate dehydrogenase, the following diseases need to be considered: 1, heart disease, such as myocarditis, acute heart attack, according to the patient’s clinical manifestations and monitoring troponin, myoglobin and electrocardiogram changes, to make a clear diagnosis in a timely manner; 2, acute hepatitis, cirrhosis, obstructive jaundice and other liver diseases, the patient needs to carry out abdominal CT and ultrasound and other related examinations to 3. Malignant tumors, such as lymphoma, require biopsy for pathological testing; 4. Skeletal muscle injury, lung disease, and kidney disease require detailed medical history and relevant tests to make a definitive diagnosis. Creatine kinase exists in skeletal muscle, heart muscle, and smooth muscle in the human body, and is more abundant in these tissues, while lactate dehydrogenase exists in almost all kinds of tissues in the body, so the specificity of these two enzymes for disease diagnosis is poor.