There are many clinical causes that can cause depression, including: 1. Psychosocial environmental factors: such as major sudden or negative life events lasting more than 2-3 months, which have an adverse effect on the individual, or even malignant stimuli leading to the occurrence of depression, causing important effects. Major negative life events, such as the death of a loved one or the loss of a relationship, are direct causes of depression; unsatisfactory marital status is an important risk factor for the occurrence of depression; key members of low-income families are prone to depression; 2. Genetic factors: If there are depressed people in the family, the likelihood of family members suffering from the disease will be high. But not all people with depression in the family will get depression, not all people with depression will have a family history, genetics is only one of the causes of depression; 3, childhood experience: adverse childhood experiences often constitute an important risk factor for depression in adulthood, such as the loss of both parents in childhood, lack of parental care in childhood, abuse, long-term life in a relatively closed environment, etc.; 4 The probability of depression is higher in introverted people than in extroverted people. The typical characteristics of introverts are pessimism, negativity, low self-esteem, like to be quiet, etc. When they encounter unhappy things, they often deal with them in a simple way and will not confide in others, but will only be smothered in their hearts, which will cause harm to themselves or others after a long time. There are also some people with anxiety, compulsive, impulsive and other personalities, also prone to depressive disorders; 5, physical diseases: especially chronic central nervous system diseases or other chronic physical diseases, can become an important risk factor for the occurrence of depressive disorders; 6, psychoactive substance abuse and withdrawal: including opiates, central stimulants, alcohol, sedative-hypnotic drugs, etc.. As more people drink alcohol and alcoholism, alcohol consumption is quite common, so it should be given special attention. It has been found that 50% or more of individuals with chronic alcohol consumption have depressive disorders. These are the common causes of depression, you can actively carry out the appropriate prevention of depression according to the causes, maintain a healthy psychology and reduce the incidence of depression.