The etiology of schizophrenia has not yet been fully elucidated, and it is generally accepted that schizophrenia is a disease process and that there may be more than one disease unit, so the prognosis for this type of disease varies widely. From a clinical perspective, the factors that influence the prognosis of schizophrenia are complex, and are roughly the following: 1) the presence or absence of a positive family history of mental illness, with a relatively poor prognosis for those with a positive family history; 2) related to typology, with the worst prognosis for the simple type, followed by the adolescent type, and relatively good for the catatonic and paranoid types. For example, patients with late-onset schizophrenia have a relatively good prognosis because their psychological structure and personality development are relatively stable, and their ability to resist external influences is relatively strong, and their personality can remain relatively intact after the disease, with almost no decline in social functioning. 4, the more positive symptoms compared to negative symptoms, the better the prognosis; conversely, the more negative symptoms, the worse the prognosis. 5. Early detection, early diagnosis and early intervention are the more important factors affecting the prognosis. Most diseases should adhere to the “three early principles”, and schizophrenia is no exception. Generally speaking, the early stage of schizophrenia is highlighted by positive symptoms, and as the disease progresses, the negative symptoms will become more and more frequent, and the effect will become worse and worse. Therefore, it is recommended that family members learn more about psychiatry, identify the problem early, consult the doctor early, make a clear diagnosis, and give the appropriate treatment in time, so that the disease can be controlled as early as possible to avoid delays. In addition, the first treatment must be adequate, with sufficient doses and courses of treatment. Each relapse aggravates the disease and increases the treatment time. The increase in the number of relapses is also one of the negative factors affecting the poor prognosis. 6, the sensitivity to drugs. In the treatment, the more sensitive to drugs, the more early to achieve better results, so that the disease is well controlled, and its prognosis is relatively good . 7, related to the season, from a clinical point of view, the disease is prone to fluctuations in the spring and/or autumn each year, so patients and families should pay attention to the observation of the disease in the corresponding seasonal changes each year, and if necessary, the specialist should make appropriate adjustments to the drugs. 8. Related to the laws of the disease itself. The individual variability of schizophrenic patients is considerable, and the level of stability of each person’s condition does not always remain at the same level, but changes dynamically like a wave, with some people fluctuating once a year or so, and others fluctuating once every three years. This requires patients and family members to pay attention to the summary of their own disease changes, to pay attention to the observation of the disease at every stage of easy fluctuations, to shorten the follow-up time, to keep in touch with the specialist, to achieve early detection and early intervention. 9. The more somatic comorbidities, the worse the prognosis. For example, the combination of serious physical illnesses, because physical illness itself can also have a negative psychosomatic impact on the patient, thus affecting the condition of schizophrenia; in addition, drug interactions can affect the efficacy. The reason for this is that the cause of schizophrenia is not completely clear, and medication is only symptomatic treatment to control symptoms, prevent relapse, and slow down the progress of the disease. Therefore, the patient’s compliance is better, the treatment actively cooperate, regular review, to ensure the smooth progress of the whole treatment, the prognosis is relatively good. 11. The better and more in place the family support (better economic base, stable family relationship, moderate emotional expression), social support (stable job and interpersonal relationship) and related other support (corresponding national policy support, recognition, tolerance and acceptance of the whole society) system, the more patients can get more support, so that patients have a good sense of belonging, which is conducive to mental recovery and enables them to able to better return to society. 12. Self-influencing factors, such as a sound personality base, a good attitude toward the disease and an optimistic and positive attitude toward people and things, rich life experience and coping skills in case of setbacks, and a relatively stable interpersonal environment are all conducive to the stability of the disease. 13. The application of second-generation new antipsychotic drugs is effective for negative symptoms, positive symptoms and cognitive impairment of schizophrenia, with few side effects, which is conducive to patients’ mental rehabilitation and thus better return to society.