When the face is frowning, three longitudinal lines appear, called “Kawasaki lines”, which are the symptoms and characteristics of facial aging. For the wrinkles that do not appear when there is no facial expression activity, Botox injection can remove them well; while for the static wrinkles that cannot be improved by Botox injection alone, combined Botox and hyaluronic acid injection is needed to achieve the effect of wrinkle removal. Botox injections are usually injected into the interbrow and descending brow muscles, which usually do not pose a greater risk. After Botox injection, many patients’ expressions will become unnatural, especially when they smile, and their expressions will be stiff. If Botox is over-injected or the injection location is too deep or too shallow, it can also cause local changes, resulting in a transient adverse reaction such as decreased muscle tone in the forehead, sagging of the skin on the forehead due to gravity, drooping of the eyelids, and changes in the shape of the eyebrows. This adverse reaction will usually slowly return to normal on its own with time as the effects of Botox wear off and is not a permanent sequela. A small number of patients may experience allergic reactions to Botox and Botox poisoning, which may even be life-threatening. After Botox injection, patients should drink more water to prevent Botox toxicity. If toxic reactions such as weakness, fever, and general itching occur, it is important to go to the hospital promptly for examination and treatment according to the doctor’s instructions.