Symptoms of buttock pain after progesterone injection: 1. When the pain symptoms are mild and of short duration, they are generally a normal physiological reaction caused by the injection of the drug. The appearance of this symptom is related to the stimulation of the local tissue by the drug. If the pain is severe or lasts for a long time, it may be because the needle is too short or too shallow in the process of progesterone injection and the drug is not well absorbed, causing painful symptoms. 3, at the same time, because progesterone is a greasy drug, the absorption process after intramuscular injection is slow, in order to avoid the formation of local hard knots, you can use a towel during Progesterone injection during the use of hot towels or potato slices hot compresses, to promote drug absorption.