Pancreatic cancer is extremely malignant, 80% of pancreatic cancer patients have lost the chance of surgery at the time of diagnosis, and 50% of them already have metastasis at the time of diagnosis, what treatment plan should be taken for these patients? Firstly, pathological diagnosis is very important. For metastatic pancreatic cancer, ultrasound gastroscopic pancreatic tumor aspiration is preferred to clarify the pathology. Secondly, the choice of chemotherapy regimen, the following are the standard regimens recommended internationally: 1, A+G regimen, albumin combined with paclitaxel combined with gemcitabine chemotherapy. 2, FOLFIRINOX, for patients in good health, you can take this program, but the side effects of this program is relatively large. 3, gemcitabine combined with the targeted drug erlotinib. 4. For patients with family history of pancreatic cancer, gemcitabine combined with cisplatin can be considered. Here, based on the experience of the Pancreatic Cancer Institute, the first option is recommended. For patients with liver metastasis, local addition of interventional chemotherapy can be considered. Thirdly, radiotherapy. For patients with more obvious pain, palliative radiotherapy can be considered. Liver metastasis of pancreatic cancer.