Elevated CA199 due to chronic cholecystitis can usually be treated with conservative observation, medications such as cefixime, and surgery. CA199 is a common tumor marker, mainly found in the gallbladder and pancreas of adults, and elevated CA199 is usually due to pancreatic cancer, gastric cancer and other diseases. If CA199 is elevated due to chronic cholecystitis, it can be treated with conservative observation or anti-infective treatment such as cefixime or cefuroxime if cancer is excluded. If CA199 is persistently and significantly elevated, it is considered to be caused by malignant tumors, which need to be diagnosed through imaging examinations and then take anti-tumor treatment such as surgery and targeted therapy. In daily life, pay attention to diet, eat more fresh vegetables and fruits, avoid overeating, spicy and stimulating food. It is recommended that patients should consult the doctor in time when any discomfort occurs, and actively treat under the guidance of professional doctors.