A burst of pain in the thigh may be due to trauma, lumbar disc herniation, cellulitis, venous embolism, osteosarcoma, etc., which need to be treated with medication or surgery according to the cause of the disease. 1. Trauma: After the thigh is violently hit, squeezed, contused, sharp instrument injury and other traumatic injuries, resulting in local skin injury, subcutaneous hematoma or even fracture, so the thigh a burst of pain. Depending on the situation, surgical disinfection and debridement, suture and bandage or surgical treatment is needed. 2. Lumbar disc herniation: After the lumbar disc herniation, the spinal nerve root is compressed, resulting in pain in the innervated sciatic nerve and this symptom. It needs to be treated with non-steroidal anti-inflammatory drugs such as ibuprofen and celecoxib, or through massage, traction, physical therapy and surgery. 3. Cellulitis: The symptom occurs when the subcutaneous connective tissue in the thigh area becomes septic due to bacterial infection. Antibacterial drugs such as metronidazole, penicillin, azithromycin and doxycycline need to be applied. 4. Venous embolism: the lower extremity venous thrombosis leads to vascular embolism, venous return obstruction and the symptoms. Warfarin, heparin and other drugs can be applied to anticoagulation therapy, or thrombolytic drugs such as urokinase can be used for treatment. 5. Osteosarcoma: malignant neoplastic lesions in the femur and other parts of the lower limbs, which can be treated by preoperative chemotherapy, surgery and postoperative adjuvant chemotherapy. Pay attention to the use of drugs under the guidance of the physician, a burst of pain in the thigh may be related to a variety of factors, it is recommended to consult a doctor for a clear diagnosis.