Cirrhosis with splenomegaly belongs to the decompensated stage of cirrhosis, which is a serious lesion and requires patients to go to the hospital for treatment as soon as possible. The presence of splenomegaly indicates that the patient is in the decompensated stage of cirrhosis. Portal hypertension and hypersplenism lead to splenomegaly. Hypersplenism affects the hematopoietic function of the spleen, resulting in anemia and bleeding. Meanwhile, due to liver hypoplasia, patients may also have digestive disorders such as dyspepsia, loss of appetite and even ascites, black stools and vomiting of blood, which may lead to hepatic encephalopathy in severe cases, jeopardizing the life and health of patients. For cirrhosis, it is necessary to adopt appropriate liver-protecting and liver-protecting treatments according to the cause of the disease, and at the same time, improve the patient’s physical condition, so as to minimize the impact of complications on the patient. Surgery can be used to control the symptoms of hypersplenism in patients with splenomegaly. For the symptoms of splenomegaly in cirrhosis, patients should consult the doctor in time and receive targeted treatment according to the doctor’s instructions.